Publications
2025
Montgomery, A., Westphal, J. Bryan, A.E., Harris, G.M., Dynamically changing extracellular matrix stiffness drives Schwann cell phenotype. Matrix Biology Plus. Volume 25, 100167, 2025.
https://doi.org/10.1016/j.mbplus.2024.100167
2024
Montgomery, Bryan, Andrew and Krutko, Maksym and Rebholz, Sandra and Marquez, Lindsey and Busch, Emma and Dong, Kevin and Pixley, Sarah and Cushion, Melanie and Esfandiari, Leyla and Harris, Greg, Development of a Bioactive, Piezoelectric PVDF-TrFE Scaffold to Modulate Wound Response in the Peripheral Nervous System.
http://dx.doi.org/10.2139/ssrn.5055754
Krutko, M, Poling, H.M., Bryan, A.E., Sharma, M., Singh, A., Reza, H.A., Wikenheiser-Brokamp, K.A., Takebe, T., Helmrath, M.A., Harris, G.M.*, Esfandiari, L.*, Enhanced Piezoelectric Performance of PVDF-TrFE Nanofibers through Annealing for Tissue Engineering Applications. bioRxiv 2024.08.16.608345
https://doi.org/10.1101/2024.08.16.608345
2023
Westphal, J.A.; Bryan, A.E.; Krutko, M.; Esfandiari, L.; Schutte, S.C.; Harris, G.M. Innervation of an Ultrasound-Mediated PVDF-TrFE Scaffold for Skin-Tissue Engineering. Biomimetics 2024, 9, 2.
doi.org/10.3390/biomimetics9010002
Bryan, A.E., Krutko, M, Westphal, J.E., Sheth, M., Esfandiari, L., Harris, G.M.; Ultrasound-Activated Piezoelectric Polyvinylidene Fluoride–Trifluoroethylene Scaffolds for Tissue Engineering Applications, Military Medicine, Volume 188, 2023, Pages 61–66
https://doi.org/10.1093/milmed/usad018
2022
Smith, C.S., Orkwis, J.A., Bryan, A.E., Xu, Z., Harris, G.M., The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity, European Journal of Cell Biology. 2022: 101(4) p: 151277
https://doi.org/10.1016/j.ejcb.2022.151277
Orkwis, J.A., Wolf, A.K., Mularczyk, Z.J., Bryan, A.E., Smith, C.S., Brown, R., Krutko, M., McCann, A., Collar, R.M., Esfandiari, L., Harris, G.M., Mechanical stimulation of a bioactive, functionalized PVDF-TrFE scaffold provides electrical signaling for nerve repair applications. Biomaterials Advances. 2022: 140: p. 213081
https://doi.org/10.1016/j.bioadv.2022.213081
2021
Xu Z, Orkwis JA, Harris GM. Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases. International Journal of Molecular Sciences. 2021; 22(9):4821.
https://doi.org/10.3390/ijms22094821
Siddiqui, A.M.; Brunner, R.; Harris, G.M.; Miller, A.L., II; Waletzki, B.E.; Schmeichel, A.M.; Schwarzbauer, J.E.; Schwartz, J.; Yaszemski, M.J.; Windebank, A.J.; Madigan, N.N. Promoting Neuronal Outgrowth Using Ridged Scaffolds Coated with Extracellular Matrix Proteins. Biomedicines 2021; 9, 479.
https://doi.org/10.3390/biomedicines9050479
2020
Cady, E.; Orkwis, J.A.; Weaver, R.; Conlin, L.; Madigan, N.N.; Harris, G.M. Micropatterning Decellularized ECM as a Bioactive Surface to Guide Cell Alignment, Proliferation, and Migration. Bioengineering 2020, 7, 102.
https://doi.org/10.3390/bioengineering7030102
Jafari, M., Vishnu, S., Xu, Z., Harris, G.M., Lee, J.Y., Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy, Carbohydrate Polymers, 2020 (249): 116837
https://doi.org/10.1016/j.carbpol.2020.116837
Orkwis, J. A., Wolf, A. K., Shahid, S. M., Smith, C., Esfandiari, L., Harris, G. M., Development of a Piezoelectric PVDF‐TrFE Fibrous Scaffold to Guide Cell Adhesion, Proliferation, and Alignment. Macromol. Biosci. 2020: 2000197.
https://doi.org/10.1002/mabi.202000197
Xu, Z., Orkwis, J. A., Harris, G. M. Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification. J. Vis. Exp. 2020. (160): e61496.
https://dx.doi.org/10.3791/61496
Abu-Niaaj, L.F., Harris, G.M. and Pixley, S.; The Role of Magnesium Biodegradable Material in Peripheral Nerve Repair. The FASEB Journal. 2020. (34): 1-1.
https://doi.org/10.1096/fasebj.2020.34.s1.06824
Xu, Z.; Orkwis, J.A.; DeVine, B.M.; Harris, G.M.; Extracellular Matrix Cues Modulate Schwann Cell Morphology, Proliferation, and Protein Expression. Journal of Tissue Engineering and Regenerative Medicine. 2020. 14(2): p. 229-242.
https://doi.org/10.1002/term.2987
2019
Siddiqui, Ahad M.; Brunner, Rosa; Harris, Greg M; Miller, Alan L.; Waletzki, Brian E.; Schwarzbauer, Jean E.; Schwartz, Jeffrey; Yaszemski, Michael J.; Windebank, Anthony J.; Madigan, Nicolas N.; Promoting Neuronal Outgrowth Using Ridged Scaffolds Coated with Extracellular Matrix Proteins. bioRxiv: 2019.
https://doi.org/10.1101/788539
Chen, Jeffrey W.*; Lim, Kelly*; Bandini, Stephen B.*; Harris, Greg M.*; Spechler, Joshua A.; Arnold, Craig B.; Fardel, Romain; Schwarzbauer, Jean E.; Schwartz, Jeffrey; Controlling the Surface Chemistry of a Hydrogel for Spatially Defined Cell Adhesion: 2019. 11(17) p. 15411-15416.
https://doi.org/10.1021/acsami.9b04023
*Authors contributed equally
2018
Harris, Greg M.; Raitman, Irene; Schwarzbauer, Jean E (2018) Cell-Derived Extracellular Matrices. Methods Cell Biol. 143.
https://doi.org/10.1016/bs.mcb.2017.08.007
2017
Harris, Greg M.; Madigan, Nicolas N.; Lancaster, Karen Z.; Enquist, Lynn W.; Windebank, Anthony J.; Schwartz, Jeffrey; Schwarzbauer, Jean E.; Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix. Matrix Biology: 2017. 16(30)
https://doi.org/10.1016/j.matbio.2016.08.011
2014
Rutledge, Katy; Cheng, Qingsu, Pryzhkova, Marina V.; Harris, Greg M.; Jabbarzadeh, Ehsan; Enhanced Differentiation of Human Embryonic Stem Cells on ECM-Containing Osteomimetic Scaffolds for Bone Tissue Engineering. Tissue Engineering Part C: 2014. 20(11)
https://doi.org/10.1089/ten.tec.2013.0411
Pryzhkova, Marina V.; Aria, Indrat; Cheng, Qingsu; Harris, Greg M.; Zan, Xingjie; Gharib, Morteza; Jabbarzadeh, Ehsan; Carbon Nanotube-based Substrates for Modulation of Human Pluripotent Stem Cell Fate. Biomaterials: 2014. 35(18): p. 5098-5109.
https://doi.org/10.1016/j.biomaterials.2014.03.011
Harris, Greg M.; Piroli, Maria E.; Jabbarzadeh, Ehsan; Deconstructing the Roles of Matrix Elasticity and Geometry in Mesenchymal Stem Cell Lineage Commitment. Advanced Functional Materials, 2014. 24(16): p. 2396-2403.
https://doi.org/10.1002/adfm.201303400
Cheng, Qingsu; Harris, Greg M.; Blais, Marc-Olivier; Rutledge, Katy; Jabbarzadeh, Ehsan; Alignment of Carbon Nanotubes to Direct Single Cell Function. NanoLife, 2014. 4(1).
https://doi.org/10.1142/S1793984414500020
2013
Cheng, Qingsu; Blais, Marc-Olivier; Harris, Greg M.; Jabbarzadeh, Ehsan; PLGA-Carbon Nanotube Conjugates for Intercellular Delivery of Caspase-3 into Osteosarcoma Cells. Plos One, 2013. 8(12): p. e81947.
https://doi.org/10.1371/journal.pone.0081947
Harris, Greg M.; Shazly, Tarek; Jabbarzadeh, Ehsan; Deciphering the Combinatorial Roles of Geometric, Mechanical, and Adhesion Cues in Regulation of Cell Spreading. Plos One, 2013. 8(11): p. e81113.
https://doi.org/10.1371/journal.pone.0081113
Pryzhkova, Marina V.; Harris, Greg M.; Ma, Shuguo; Jabbarzadeh, Ehsan; Patterning Pluripotent Stem Cells at a Single Cell Level. Journal of Biomaterials and Tissue Engineering, 2013. 3(4): p. 461-471.
https://doi.org/10.1166/jbt.2013.1106
Harris, Greg M.; Rutledge, Katy; Cheng, Qingsu; Blanchette, James; Jabbarzadeh, Ehsan; Strategies to Direct Angiogenesis within Scaffolds for Bone Applications. Current Pharmaceutical Design, 2013. 19(19): p. 3456-3465.
https://doi.org/10.2174/1381612811319190011
Montgomery, A., Westphal, J. Bryan, A.E., Harris, G.M., Dynamically changing extracellular matrix stiffness drives Schwann cell phenotype. Matrix Biology Plus. Volume 25, 100167, 2025.
https://doi.org/10.1016/j.mbplus.2024.100167
2024
Montgomery, Bryan, Andrew and Krutko, Maksym and Rebholz, Sandra and Marquez, Lindsey and Busch, Emma and Dong, Kevin and Pixley, Sarah and Cushion, Melanie and Esfandiari, Leyla and Harris, Greg, Development of a Bioactive, Piezoelectric PVDF-TrFE Scaffold to Modulate Wound Response in the Peripheral Nervous System.
http://dx.doi.org/10.2139/ssrn.5055754
Krutko, M, Poling, H.M., Bryan, A.E., Sharma, M., Singh, A., Reza, H.A., Wikenheiser-Brokamp, K.A., Takebe, T., Helmrath, M.A., Harris, G.M.*, Esfandiari, L.*, Enhanced Piezoelectric Performance of PVDF-TrFE Nanofibers through Annealing for Tissue Engineering Applications. bioRxiv 2024.08.16.608345
https://doi.org/10.1101/2024.08.16.608345
2023
Westphal, J.A.; Bryan, A.E.; Krutko, M.; Esfandiari, L.; Schutte, S.C.; Harris, G.M. Innervation of an Ultrasound-Mediated PVDF-TrFE Scaffold for Skin-Tissue Engineering. Biomimetics 2024, 9, 2.
doi.org/10.3390/biomimetics9010002
Bryan, A.E., Krutko, M, Westphal, J.E., Sheth, M., Esfandiari, L., Harris, G.M.; Ultrasound-Activated Piezoelectric Polyvinylidene Fluoride–Trifluoroethylene Scaffolds for Tissue Engineering Applications, Military Medicine, Volume 188, 2023, Pages 61–66
https://doi.org/10.1093/milmed/usad018
2022
Smith, C.S., Orkwis, J.A., Bryan, A.E., Xu, Z., Harris, G.M., The impact of physical, biochemical, and electrical signaling on Schwann cell plasticity, European Journal of Cell Biology. 2022: 101(4) p: 151277
https://doi.org/10.1016/j.ejcb.2022.151277
Orkwis, J.A., Wolf, A.K., Mularczyk, Z.J., Bryan, A.E., Smith, C.S., Brown, R., Krutko, M., McCann, A., Collar, R.M., Esfandiari, L., Harris, G.M., Mechanical stimulation of a bioactive, functionalized PVDF-TrFE scaffold provides electrical signaling for nerve repair applications. Biomaterials Advances. 2022: 140: p. 213081
https://doi.org/10.1016/j.bioadv.2022.213081
2021
Xu Z, Orkwis JA, Harris GM. Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases. International Journal of Molecular Sciences. 2021; 22(9):4821.
https://doi.org/10.3390/ijms22094821
Siddiqui, A.M.; Brunner, R.; Harris, G.M.; Miller, A.L., II; Waletzki, B.E.; Schmeichel, A.M.; Schwarzbauer, J.E.; Schwartz, J.; Yaszemski, M.J.; Windebank, A.J.; Madigan, N.N. Promoting Neuronal Outgrowth Using Ridged Scaffolds Coated with Extracellular Matrix Proteins. Biomedicines 2021; 9, 479.
https://doi.org/10.3390/biomedicines9050479
2020
Cady, E.; Orkwis, J.A.; Weaver, R.; Conlin, L.; Madigan, N.N.; Harris, G.M. Micropatterning Decellularized ECM as a Bioactive Surface to Guide Cell Alignment, Proliferation, and Migration. Bioengineering 2020, 7, 102.
https://doi.org/10.3390/bioengineering7030102
Jafari, M., Vishnu, S., Xu, Z., Harris, G.M., Lee, J.Y., Fucoidan-Doxorubicin Nanoparticles Targeting P-Selectin for Effective Breast Cancer Therapy, Carbohydrate Polymers, 2020 (249): 116837
https://doi.org/10.1016/j.carbpol.2020.116837
Orkwis, J. A., Wolf, A. K., Shahid, S. M., Smith, C., Esfandiari, L., Harris, G. M., Development of a Piezoelectric PVDF‐TrFE Fibrous Scaffold to Guide Cell Adhesion, Proliferation, and Alignment. Macromol. Biosci. 2020: 2000197.
https://doi.org/10.1002/mabi.202000197
Xu, Z., Orkwis, J. A., Harris, G. M. Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification. J. Vis. Exp. 2020. (160): e61496.
https://dx.doi.org/10.3791/61496
Abu-Niaaj, L.F., Harris, G.M. and Pixley, S.; The Role of Magnesium Biodegradable Material in Peripheral Nerve Repair. The FASEB Journal. 2020. (34): 1-1.
https://doi.org/10.1096/fasebj.2020.34.s1.06824
Xu, Z.; Orkwis, J.A.; DeVine, B.M.; Harris, G.M.; Extracellular Matrix Cues Modulate Schwann Cell Morphology, Proliferation, and Protein Expression. Journal of Tissue Engineering and Regenerative Medicine. 2020. 14(2): p. 229-242.
https://doi.org/10.1002/term.2987
2019
Siddiqui, Ahad M.; Brunner, Rosa; Harris, Greg M; Miller, Alan L.; Waletzki, Brian E.; Schwarzbauer, Jean E.; Schwartz, Jeffrey; Yaszemski, Michael J.; Windebank, Anthony J.; Madigan, Nicolas N.; Promoting Neuronal Outgrowth Using Ridged Scaffolds Coated with Extracellular Matrix Proteins. bioRxiv: 2019.
https://doi.org/10.1101/788539
Chen, Jeffrey W.*; Lim, Kelly*; Bandini, Stephen B.*; Harris, Greg M.*; Spechler, Joshua A.; Arnold, Craig B.; Fardel, Romain; Schwarzbauer, Jean E.; Schwartz, Jeffrey; Controlling the Surface Chemistry of a Hydrogel for Spatially Defined Cell Adhesion: 2019. 11(17) p. 15411-15416.
https://doi.org/10.1021/acsami.9b04023
*Authors contributed equally
2018
Harris, Greg M.; Raitman, Irene; Schwarzbauer, Jean E (2018) Cell-Derived Extracellular Matrices. Methods Cell Biol. 143.
https://doi.org/10.1016/bs.mcb.2017.08.007
2017
Harris, Greg M.; Madigan, Nicolas N.; Lancaster, Karen Z.; Enquist, Lynn W.; Windebank, Anthony J.; Schwartz, Jeffrey; Schwarzbauer, Jean E.; Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix. Matrix Biology: 2017. 16(30)
https://doi.org/10.1016/j.matbio.2016.08.011
2014
Rutledge, Katy; Cheng, Qingsu, Pryzhkova, Marina V.; Harris, Greg M.; Jabbarzadeh, Ehsan; Enhanced Differentiation of Human Embryonic Stem Cells on ECM-Containing Osteomimetic Scaffolds for Bone Tissue Engineering. Tissue Engineering Part C: 2014. 20(11)
https://doi.org/10.1089/ten.tec.2013.0411
Pryzhkova, Marina V.; Aria, Indrat; Cheng, Qingsu; Harris, Greg M.; Zan, Xingjie; Gharib, Morteza; Jabbarzadeh, Ehsan; Carbon Nanotube-based Substrates for Modulation of Human Pluripotent Stem Cell Fate. Biomaterials: 2014. 35(18): p. 5098-5109.
https://doi.org/10.1016/j.biomaterials.2014.03.011
Harris, Greg M.; Piroli, Maria E.; Jabbarzadeh, Ehsan; Deconstructing the Roles of Matrix Elasticity and Geometry in Mesenchymal Stem Cell Lineage Commitment. Advanced Functional Materials, 2014. 24(16): p. 2396-2403.
https://doi.org/10.1002/adfm.201303400
Cheng, Qingsu; Harris, Greg M.; Blais, Marc-Olivier; Rutledge, Katy; Jabbarzadeh, Ehsan; Alignment of Carbon Nanotubes to Direct Single Cell Function. NanoLife, 2014. 4(1).
https://doi.org/10.1142/S1793984414500020
2013
Cheng, Qingsu; Blais, Marc-Olivier; Harris, Greg M.; Jabbarzadeh, Ehsan; PLGA-Carbon Nanotube Conjugates for Intercellular Delivery of Caspase-3 into Osteosarcoma Cells. Plos One, 2013. 8(12): p. e81947.
https://doi.org/10.1371/journal.pone.0081947
Harris, Greg M.; Shazly, Tarek; Jabbarzadeh, Ehsan; Deciphering the Combinatorial Roles of Geometric, Mechanical, and Adhesion Cues in Regulation of Cell Spreading. Plos One, 2013. 8(11): p. e81113.
https://doi.org/10.1371/journal.pone.0081113
Pryzhkova, Marina V.; Harris, Greg M.; Ma, Shuguo; Jabbarzadeh, Ehsan; Patterning Pluripotent Stem Cells at a Single Cell Level. Journal of Biomaterials and Tissue Engineering, 2013. 3(4): p. 461-471.
https://doi.org/10.1166/jbt.2013.1106
Harris, Greg M.; Rutledge, Katy; Cheng, Qingsu; Blanchette, James; Jabbarzadeh, Ehsan; Strategies to Direct Angiogenesis within Scaffolds for Bone Applications. Current Pharmaceutical Design, 2013. 19(19): p. 3456-3465.
https://doi.org/10.2174/1381612811319190011
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